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Infection and Inflammation Imaging

Using scanning and image reconstruction techniques to give clinicians new insights into a range of inflammatory conditions and infections

What does this
Theme Involve?

Medical Imaging plays a major role in diseases characterised by inflammation, infection or abnormal immunology. UCL is pioneering development of medical imaging in this field and has in place a robust infrastructure across the campus linking pre-clinical and clinical research groupings. We have a particular emphasis on clinical translation in high impact disease areas and by way of example have programmes investigating novel imaging techniques, computational models of biological systems and automated processing of complex imaging data.

There are a number of key areas in urgent need of development and innovation, such as in Crohn’s disease, chronic obstructive pulmonary disease, Barrett’s oesophagus, and liver fibrosis and cirrhosis.

Partners and Facilities

The programme is spread throughout UCL Partners harnessing the world leading clinical expertise with rich patient cohorts. The Centre has access to an unparalleled range of platforms for human imaging including several clinical multi-detector row CT and MR scanners, a 3T Philips research magnet, and a Philips interventional 3T magnet and Siemens PET/MRI

Studying Under This Theme

Projects listed below are available for applicants to include in their 5 project choices. Successful candidates will meet with both primary supervisors from their selection before being assigned to their allocated research project to ensure that each student gets the best opportunity for their skills and development. To view all available project videos please visit our YouTube channel.

Theme Leader

Prof Stuart Taylor
UCL Centre for Medical Imaging

My MD thesis concerned CT colonography, then in its infancy. Many of the resulting publications were the first descriptions of technical optimisation worldwide and provided the first insights into physician training and patient experience.

To date I am in the top 3 most published authors on CT colonography in the world. I was first author on the pan European consensus statement on CT colonography, and provided advice to the Chinese government on implementation. I am asked to speak on the subject both nationally and internationally (for example Japan, China, USA as well as Europe). I lead the new 3T MRI research facility at UCLH and am building research programs in pelvic floor imaging, imaging inflammatory bowel disease and functional MRI in the assessment of inflammation and perfusion.

In particular I am developing a translational research program into functional MRI techniques with applications in many clinical areas, for example, oncology (eg paediatric lymphoma), thoracic medicine (characterization of mediastinal lymphadenopathy), hepatology and bowel (particularly in inflammatory bowel disease). For example we have recently demonstrated for the first time that MRI perfusion measurements can predict angiogenesis in crohns disease, and have received a CRUK BIDD award to investigate the use of MRI in staging lymphoma. I am also part of a consortium developing a computer model of the GI tract with reference to MRI in Crohns disease, awarded 3M Euros from the EU FP7 scheme. I am the academic lead for the Walport ACF scheme in clinical radiology at UCL.

IRIS profile

Available Projects:

The Role of Dynamic MRI for the Quantitative Investigation of Gastrointestinal Physiology in Health and Disease