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Dr Martin Pule

UCL Cancer Institute

3rd Floor, Charles Bell House

67 Riding House Street

London

W1P 7NN

Biography

Dr Martin Pule is a Senior Lecturer in Haematology, UCL Cancer Institute. Martin leads optical imaging in the UCL Centre for Biological Imaging. He and his group work on engineering mammalian cells for therapeutic applications. Most of their work involves engineering proteins and vectors for eukaryotic expression, testing in small animals and then with some promising approaches, moving to clinical studies. While working in Baylor College of Medicine, Houston, as a traveling Fulbright scholar, Martin was the first to describe third generation forms of these CARS2 which transmit activation, proliferation and survival signal to the transduced T-cells, the form of which have used as a template for many different chimeric antigen receptors since. While at Baylor Martin also engineered a novel suicide gene, “iCasp9”3, which is in widespread use and currently in clinical studies. Martin’s work in Baylor culminated in testing of a CAR in clinical study in children with a solid cancer called neuroblastoma4. This was the first demonstration of clinical efficacy of this approach and was published in Nature Medicine paper, along with a covering editorial. Martin as well as being a senior Lecturer in UCL, holds an honorary consultant post as a clinical haematologist in the UCL Hospital (UCLH). He is also the principle investigator in an open clinical study of engineered T-cells in UCLH.

IRIS profile

Available Projects:

Therapeutic T-cells Imaging