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UPDATE: We are delighted to announce that EPSRC have funded our CDT for five more years under the new name EPSRC Centre for Doctoral Training in Intelligent Integrated Imaging in Healthcare (i4health).

Visit our new website at:

Dr David Thomas

UCL Institute of Neurology

Neuroimaging Analysis Centre
Department of Brain Repair and Rehabilitation
8-11 Queen Square


I am the principal MRI physicist at the Leonard Wolfson Experimental Neurology Centre (LWENC; see, working on the development and optimization of novel MR sequences that are sensitive to the early pathological changes which occur in neurodegenerative disease. This includes both high-resolution 3D anatomical scanning methods, which depict locations of brain atrophy and abnormality, and methods which measure changes in tissue physiology, e.g. fMRI, cerebral blood flow using arterial spin labeling (ASL), pH and protein accumulation using chemical exchange saturation transfer (CEST). The principal aim of my work is to develop non-invasive biomarkers which can be used to identify disease onset at the earliest stages, and to monitor the efficacy of therapeutic interventions which are being trialed for the first time in man at the LWENC.

IRIS profile