Optimised Arterial Spin Labelling for Non-Invasive Blood Flow Measurements in Children with Cancer and Vascular Disease
Development of optimized arterial spin labeling (ASL) acquisition techniques for measuring blood flow using MRI is challenging, but clinically important, in specific regions of the brain. For example, a large number of childhood brain tumours occur in infratentorial regions, or close to the pituitary gland and optic chiasm. This project is focused on the development of ASL protocols that are optimised for use in these regions and would allow reliable assessment of haemodynamic behaviour in many childhood tumours and in vascular disease. Development of ‘real-time’ optimisation of ASL acquisition parameters such as the choice of appropriate ‘inflow’ times will allow rapid acquisition that would be practical in the clinical setting.