Novel Imaging Biomarker Development for Detecting Pre-manifest Changes in Huntington’s Disease with Advanced Diffusion MRI
Huntington’s disease (HD) is a neurodegenerative genetic disorder that at present has no cure. Track-On HD, a ground-breaking study led by Prof Tabrizi, aims to identify robust markers of the most subtle signs of the disease so that novel therapeutics can be developed to target the condition at the earliest opportunity. Among its many innovations, the study will scan its cohort with NODDI, one of the most advanced diffusion MRI techniques today. This project will exploit this first-of-its-kind resource, together with the study’s well-characterised cohort, to develop and validate next-generation imaging biomarkers that combine brain tissue microstructure with connectivity in a unified framework.