Multi-parametric Imaging Using Hybrid PET/MRI to Investigate Neurological Disorders
Allocated in Academic year 2015-16
Compared to most systems in the body the brain is poorly understood and treatment of life-threatening conditions is in its infancy. Imaging can provide useful insight to a number of neurological disorders (epilepsy, dementia, movement disorders) and has potential to detect disease at an early stage of development and to better stratify patients. For example, there is recognition that dementia poses a major problem in the aging population with significant related economic consequences; early detection may permit treatment prior to irreversible damage. Despite more than three decades of neuroimaging research involving complex brain scanning, relatively few imaging tools are in routine clinical use. There continues to be many technological challenges in establishing robust analysis methods, applicable in the clinical setting.
Projects in this field will include development of techniques: – To investigate the robustness of imaging biomarkers currently used in research in providing useful clinical information. – To investigate methods to combine multi-dimensional data sets to create robust biomarkers for investigating underlying mechanisms of neurological diseases. – To develop quantitative biomarkers for novel PET tracers, used in combination with MRI