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14 Mar

Merit Abstract Award for student paper on multimodal imaging for Alzheimer's

by Benedetta Biffi

CDT student Marzia Scelsi has received a Merit Abstract Award for the 2017 OHBM Annual Meeting, taking place in Vancouver, Canada in June.

The Organization for Human Brain Mapping (OHBM) is the primary international organization dedicated to using neuroimaging to discover the organization of the human brain. The paper by M. Scelsi et al., “Multimodal Imaging Disease Progression Scores as Quantitative Traits in GWAS of the ADNI Cohort”, will be featured at their next Annual Meeting, taking place in Vancouver, in an oral session on Neurological Disorders. Over 3000 attendees are expected at the event.


Quantitative trait genome-wide association studies (GWAS) in late-onset Alzheimer’s disease (AD) using imaging biomarkers focused either on cross-sectional or on longitudinal phenotypes derived from a single imaging modality. However, since clinical and imaging biomarkers in AD are highly interrelated, association studies based on single biomarkers may miss genetic factors influencing their joint variation. In order to account for their joint variability, in this work we propose to use two well-established AD biomarkers to define a disease progression score (DPS), and to subsequently perform a GWAS using this DPS as a novel quantitative phenotype.

M. A. Scelsi, M. Lorenzi, J. M. Schott, S. Ourselin, A. Altmann, “Multimodal Imaging Disease Progression Scores as Quantitative Traits in GWAS of the ADNI Cohort”


Benedetta Biffi

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