Hepatic Arterial Spin Labelling
Allocated in Academic Year 2016-2017
The liver is a unique organ, as it has a dual blood supply: one supplying arterial blood, and the other delivering blood for filtering. A number of diseases are characterised by altered liver blood flow, such as cancer and cirrhosis, and non-invasive techniques for measuring liver blood flow in the clinic are in critical need. We are developing a method known as hepatic arterial spin labelling (hASL) which is based on MRI, and uses the flow of water in the blood to estimate blood flow. The benefit of ASL is its potential to separate out each blood supply, and therefore to distinguish normal from diseased livers and inform on effective therapeutic response. The aim of the project is to develop clinically translatable techniques that can inform patient management in a clinical setting.