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13 Jan

Dr Kev Dhaliwal and Prof Mark Bradley - Lighting Up the Lung

by Benedetta Biffi
Clinical Seminar
Tuesday 13 Jan, 6pm

Abstract: Professor Mark Bradley and Dr Kev Dhaliwal will present an overview of their joint research programme to develop optical translational tools in diseases of high unmet need. The talk will outline the ‘journey’ of taking concepts from bench to man including the hurdles, pain and joy that it entails. Mark and Kev are supported by the EPSRC, MRC and Wellcome Trust in the field of optical molecular imaging and sensing of lung disease.

Professor Mark Bradley is Professor of High-Throughput Chemical Biology in the School of Chemistry at The University of Edinburgh.

Mark received his doctorate from the University of Oxford in 1989 under the supervision of Professor Sir Jack Baldwin, followed by post-doctoral studies at Harvard Medical School and returned to the UK as a Royal Society Fellow at Southampton University in the early 90’s. In 1997 at the age of 33 he was made a Professor of Combinatorial Chemistry. He has been elected to fellowships of both the Royal Society of Chemistry and the Royal Society of Edinburgh, and has held the Novartis Young Investigator Award, the Zeneca Research Award for Organic Chemistry, the GlaxoWellcome Award for Innovative Chemistry, the Pfizer Award in Organic chemistry and more recently, the Novartis Chemistry Lectureship and the Award from the Society of Combinatorial Sciences. In 2011 he was awarded the Chancellors Award for research. His group has published over 300 peer reviewed papers and 20 patents and more than 65 PhD students have graduated from his group.

Three research themes dominate in his group at this time:

(i). The development and exploitation of polymer microarray technology for the identification and application of polymers for controlling and modulating cells.

(ii). The development of “smart” fluorescent reporters for in vivo based optical molecular imaging.

(iii). In vivo catalytic chemistry.

Dr Kev Dhaliwal is a Senior Clinical Lecturer in Pulmonary Molecular Imaging and an Honorary Consultant in Respiratory Medicine (University of Edinburgh).

He subspecialises in Pulmonary Infection and Tuberculosis. He undertook a BSc in Medical Microbiology and a PhD in Optical Molecular Imaging and Lung Inflammation. He currently performs translational research in collaboration with physical scientists in applying methodologies for imaging inflammation in man.

Kev has worked closely with Professor Mark Bradley for the past 7 years to develop a lung focused molecular imaging strategy. Kev is the Chief Investigator of 5 upcoming ‘first in man’ trials of optical molecular imaging reagents and 2 medical devices.

With Mark, he leads an interdisciplinary ‘hub’ within the Queen’s Medical Research Institute in the College of Medicine, which is facilitating “into man’ Chemistry, Optical Device Manufacture and Translational Physical Science. This hub co-locates clinicians, biologists, chemists, engineers, optical physicists, signal processors and machine learners.


Benedetta Biffi

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