Development of PET-based Myocardial Perfusion Model
Allocated in academic year 2015-16
To derive clinically important haemodynamic parameters to evaluate the severity of coronary atherosclerosis, such as fractional flow reserve, computational fluid dynamics (CFD) has been used with 3D model of the vasculature reconstructed from CT images. In this project, we will develop a mathematical model of myocardial perfusion to be integrated with the CFD model of upstream epicardial coronary arteries, based on a large number of PET-CT scan data at UCLH. Successful development will contribute to more accurate prediction of those haemodynamic parameters noninvasively and to better understanding of the interaction between epicardial coronary artery haemodynamics and myocardial perfusion, in the context of coronary atherosclerosis development and myocardial infarction.
Related Methodological Themes