Development of Novel Structural Connectivity Measures for Application to Multiple Time-point Imaging Data in Huntington’s Disease Patients
Huntington’s disease (HD) is a progressive neurodegenerative disease that causes significant cognitive and motor dysfunction. MRI plays an important role in monitoring brain atrophy and diffusion MRI methods in particular can be used to characterize changes in brain connectivity. This project focuses on the development of novel tractography based methods for capturing changes in the patterns of brain connectivity. These approaches include various graph theoretical approaches. Amongst these we wish to identify which provide the best prediction of outcome and which can provide new insights into the nature of brain microstructural changes that underpin the disease.