Development of New MRI Models of Tumour Blood Flow, Hypoxia and Glycolysis using Mathematical Modelling
Allocated in Academic Year 2016-2017
Despite its fundamental importance to understanding and treating tumour pathologies, the subtle correlation between tumour blood flow, hypoxia and glycolysis remains elusive to predict. This project will address this unmet clinical need by developing new mathematical models of tumour blood flow, oxygenation and glycolysis, parameterised by explicit data on tumour vascular structures down to the smallest capillaries. The model predictions will be compared against our latest MRI data from head and neck cancer patients, and will direct the development of new MRI protocols.