Applying MRI Susceptibility Mapping to Improve Diagnosis and Prognosis in Cancer
Allocated in academic year 2015-16
Applying MRI Susceptibility Mapping to Improve Diagnosis and Prognosis in Cancer Hypoxia is found in many tumours and is emerging as a useful indicator of tumour grade and a biomarker for poor response to (radio)therapy. The clinical challenge is to determine the oxygenation levels inside tumours non-invasively. MRI susceptibility mapping uses MRI phase images to calculate the local tissue magnetic susceptibility. The susceptibility of blood changes dramatically depending on its oxygenation making MRI susceptibility mapping an ideal candidate to reveal oxygenation in vivo. In addition to expertise in susceptibility mapping techniques, we have access to unique clinical datasets with MRI phase images in both prostate cancer patients and those with head and neck cancers as well as the possibility of acquiring new MRI data optimised for susceptibility mapping.