Advanced Imaging Techniques For the Monitoring of Innovative Approaches in Regenerative Medicine
Allocated in Academic Year 2016-17
The clinical challenge is the development of optimized scaffolds for regenerative medicine – an area in which De Coppi’s team has obtained outstanding preliminary results with a “tissue decellularization” technique. The next challenge is the development of an imaging method that enables following up the development of such scaffolds when re-cellularized and implanted – first on pre-clinical platforms, then clinically. We have identified x-ray phase contrast as a very promising candidate, due to its extreme sensitiviy, low-dose and high penetration power which enables probing deeply implanted structures. We have run joint preliminary studies which provided extremely promising results, and this project would aim at taking the approach towards the next (e.g. pre-clinical) stage.